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1)  M receptor
M受体
1.
Effect of Daming Capsule on mRNA expression of M receptor s different isoforms on cardiac muscle of hyperlidemic rats;
大明胶囊对高脂血症大鼠心肌M受体各亚型mRNA表达的影响
2.
OBJECTIVE:To study the diaphoretic mechanisms of Mahuangtang and its relationship with M receptor.
目的:探讨麻黄汤的发汗作用机制与M受体的关系。
3.
Methods T-SOD activity,MDA level in serum,E-2 and T levels in plasma,binding capacity of M receptor,bone density of proximal,middle and distal segments of left femur,and break bending load of right femur were determined in the rats aged 6,24,and 30 months.
方法测定不同月龄SD雄性大鼠血清T-SOD活性及MDA含量、血浆E2及T的含量、脑组织M受体结合容量以及左侧股骨近段、中段、远段的骨密度和右侧股骨的弯曲断裂载荷。
2)  muscarinic receptor
M受体
1.
Application of human muscarinic receptor subtype gene transfection CHO cell line in new drug screening;
转人M受体亚型基因CHO细胞系在新药筛选中的应用
2.
Changes of 5 muscarinic receptor subtypes in scleral tissues of eyes with form deprivation myopia
形觉剥夺性近视眼巩膜组织中M受体5种亚型表达的变化
3.
Antagonist of IP_3 receptor, VDCC and muscarinic receptors were used for study.
结论:山莨菪碱抑制心室肌细胞钙瞬变和收缩功能可能与其阻断M受体、抑制细胞内钙库钙离子释放和经过电压依赖型钙离子通道的钙离子内流有关。
3)  muscarinic receptors
M受体
1.
Aim:To search for effective and selective antagonists of the muscarinic receptors,we investigated the pharmacological characteristics of novel anti-muscarinic acetylcholine agent phencynonate hydrochloride(CPG) and its derivatives suchas demethyl phencynonate hydrochloride(DMCPG) and thiencynonate hydrochloride(CTG).
方法:运用放射性配体受体结合实验,比较研究CPG、DMCPG、CTG与大鼠大脑皮层M受体的亲和性。
2.
AIM Our investigation is to screen bioactive novel compounds using the isolated rat aortic rings and depending on the similar and distinct characteristics between the endothelial target for acetylcholine(ETA) and muscarinic receptors and to investigate the mechanisms of vasodilatory effects of candidate compounds.
目的 利用ETA与M受体的相似性和差异性 ,设计合成吗啉环和哌嗪环类新结构化合物 ,分析其对血管舒张功能的影响。
3.
The functions of muscarinic receptors in the tissues innervated by the parasympathetic cholinergic postfibers, can be modulated by the ganglionic nicotinic receptors through stimulating ACh release.
如副交感神经节后N受体可通过刺激胆碱能神经纤维末梢释放ACh来调节组织中M受体的功能 ;而胆碱能神经元突触后N受体的活性也可被突触前膜上M和N的自受体通过反馈调控节前纤维ACh的释放来调节 ;另外 ,N受体被阻断或失敏后不同组织中M受体的功能会发生不同的变化 ,以将机体胆碱能神经系统维持在一个稳定状
4)  M-receptor
M受体
1.
After the treatment of estradiol, ZDYIOI or DMSO (solvent) to cultured CHOm2 cells for a certain peirod, M-receptor density was determined by 3H-NMS binding assay.
CHOm2细胞加雌二醇、ZDY101或等体积溶媒DMSO培养后通过3H-NMS结合反应测定M受体密度,并与同时加雌激素受体拮抗剂ICI-182780的细胞作对比。
5)  muscarinic acetylcholine receptor
脑M受体
1.
A new approach to the pharmacological regulation of memory:sarsasapogenin improves memory by elevating the low muscarinic acetylcholine receptor density in brains of memory-deficit rat models;
老年痴呆症药物治疗的一条新途径:知母皂甙元促进脑M受体生成改善记忆功能
6)  M-receptor
M-受体
1.
The effect of acupuncture on cholinergic M-receptor bonding capacity and cholinesterase activity in cerebral cortex of rats were determined by using Morris maze test and compared among model,acupuncture,moxibustion and control groups.
方法:建立拟痴呆大鼠动物模型,运用 Morris 迷宫作为检测工具,分别观察对照组、模型组、针刺组、艾灸组游泳时的差异及针刺、艾灸对拟痴呆大鼠大脑皮层组织中胆碱能 M-受体结合容量、胆碱酯酶活性(ACHE)的影响。
补充资料:5-羟色胺受体阻断剂
分子式:
CAS号:

性质:5-羟色胺(5-HT)是重要的神经递质,也是一种自身活性物质。5-HT通过与靶细胞膜上的5-HT受体结合并诱发生物效应。5-HT受体可分为5-HT1A,5-HT1B,5-HT1C,5-HT2,5-HT3。5-HT受体阻断药大致有以下几类,(1)麦角酸的衍生物如麦解酰二乙胺等;(2)组胺H1受体阻断药如赛庚啶等;(3)吩噻嗪类如氯丙嗪等;(4)肾上腺素α-受体阻断药如酚苄明等。常用于实验室研究、较为特异的5-HT受体阻断剂有麦角苄脂、米安色林、苯噻啶等。

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