1) Vascular endothelial growth factor receptor-3
血管内皮生长因子受体3
1.
Methods The expression of VEGF-C mRNA in 89 cases of primary breast cancer was detected by in situ hybridization,and lymphatic vessels with vascular endothelial growth factor receptor-3(VEGFR-3) were labeled by immunohistochemistry SP method.
方法:分子生物学原位杂交方法检测VEGF-C mRNA基因在89例原发性乳腺癌组织中的表达;免疫组化SP法对乳腺癌肿瘤淋巴管进行血管内皮生长因子受体3(vascu lar endothelial growth factor receptor-3,VEG-FR-3)标记。
2.
Purpose: To investigate the expressions of vascular endothelial growth factor-C (VEGF-C) and vascular endothelial growth factor receptor-3 (VEGFR-3) and their correlation with lymphangiogenesis in epithelial ovarian carcinoma.
目的:探讨血管内皮生长因子C(vascular endothelial growth factor C, VEGF-C)与血管内皮生长因子受体3(vascular endothelial growth factor receptor 3,VEGFR-3)在卵巢癌组织中的表达及其对微淋巴管生成的影响。
3.
Objective To investigate the relationship of gastric cancer in lymph node metastasis among the pathology features and the expression of vascular endothelial growth factor-D(VEGF-D),vascular endothelial growth factor receptor-3(VEGFR-3),lymphatic vessel density(LVD).
目的探讨胃癌淋巴结转移与血管内皮生长因子D(VEGF-D)、血管内皮生长因子受体3(VEGFR-3)、淋巴管密度(LVD)表达间的关系。
2) Vascular endothelial growth factor receptor 3
血管内皮生长因子受体3
1.
Objective To investigate the inhibitory effect of vascular endothelial growth factor receptor 3 (VEGFR-3) antibody on the transplantation model of human laryngeal squamous carcinoma in nude mice.
目的研究血管内皮生长因子受体3(vascular endothelial growth factor receptor3,VEGFR-3)抗体对人喉鳞癌裸鼠移植瘤模型生长的抑制作用。
2.
Objetive:To study the expression of vascular endothelial growth factor C(VEGF-C) and vascular endothelial growth factor receptor 3(VEGFR-3) in human rectal adenocarcinoma tissue and lymph nodes,and to determine the function of VEGF-C in the genesis,and the development and lymphatic metastasis of rectal adenocarcinoma.
目的:检测血管内皮生长因子C(VEGF-C)及血管内皮生长因子受体3(VEGFR-3)在人直肠癌组织和淋巴结中的表达,探讨VEGF-C在人直肠癌发生、发展和淋巴结转移中的作用。
3.
Objective To construct the small interfering RNA(siRNA)expression vector(psiRNAVEGFR-3) targeting vascular endothelial growth factor receptor 3(VEGFR-3)gene and to observe its suppressive effect on the expression of VEGFR-3 gene in human colon cancer cell line LoVo and its biologic effects.
目的构建靶向血管内皮生长因子受体3(VEGFR-3)基因的小干扰RNA(siRNA)表达载体(psiRNA-VEGFR-3),并观察其抑制人结肠癌细胞株LoVo细胞中VEGFR-3基因表达的效果及生物学效应。
3) VEGFR-3
血管内皮生长因子受体3
1.
THE EXPRESSIONS OF VEGF-D AND VEGFR-3 IN COLON CARCINOMA AND THEIR ROLE IN LYMPHATIC METASTASIS OF CARCINOMA;
血管内皮生长因子D和血管内皮生长因子受体3在人结肠癌中的表达及淋巴道转移中的作用
4) vascular endothelial growth factor receptor-3(VEGFR-3)
血管内皮生长因子受体-3(VEGFR-3)
5) Vascular endothelial growth factor receptor-3 (VEGFR-3)
血管内皮生长因子受体3(VEGFR-3)
6) VEGFR-3
血管内皮生长因子受体-3
1.
The expression of VEGFR-3 and Podoplanin in 30 paraffin-embedded samples were examined using immunohistochemistry technique.
方法用5′-核苷酸酶(5-′Nase)酶组织化学法对30例正常胃肠新鲜标本(胃及肠组织标本各15例)进行染色观察;用免疫组织化学PV9000法对30例相应胃肠标本石蜡包埋组织行血管内皮生长因子受体-3(VEGFR-3)和肾小球足突细胞膜黏蛋白(Podoplanin)染色观察。
2.
Objective To study the significance of expression of VEGF-C and VEGFR-3 in different histopathological grade of astrocytoma.
目的探讨血管内皮生长因子-C(VEGF-C)及血管内皮生长因子受体-3(VEGFR-3)在不同级别脑星形细胞瘤中的表达。
3.
To detect the expression of vascular endothelial growth factor-C(VEGF-C) , vascular endothelial growth factor receptor-3(VEGFR-3)and lymphatic-vessel density(LVD) in biopsy specimens of nasopharyngeal carcinoma (NPC) before radiotherapy and to investigate their associations with clinicopathologic characters , node recurrence and survival rate .
目的:探讨鼻咽癌放疗前活检组织中血管内皮生长因子-C(vascular endothelial growth factor-C,VEGF-C)、血管内皮生长因子受体-3 (vascular endothelial growth factor receptor-3,VEGFR-3)的表达及淋巴管密度(lymphatic-vessel density,LVD)与各临床病理参数、淋巴结复发及生存率的关系,为了解鼻咽癌淋巴道转移机制及判断预后提供新的思路。
补充资料:血管内皮生长因子
分子式:
CAS号:
性质:又称血管通透因子(vascular permeability factor)。1989首先从牛垂体滤泡状细胞培养液中分离纯化。有四种不同形式,成熟单体,分别为121,165,189和206个氨基酸,目前分离得到的VEGF,均由两个相同多肽链通过二硫键构成的同源二聚体,亚基分子量18 000~24 000,总蛋白分子量34 000~46 000。蛋白质表面有许多阳离子,呈强碱性,等电点高,对酸碱热稳定。VEGF是一类糖蛋白,可与肝素结合,多糖链仅与其分泌功能有关,与生物活性无关。VEGF 121/165为可溶性分泌蛋白。VEGF 189/206几乎都结合在质膜或基底膜上的含有肝素的蛋白聚糖上。四种VEGF的生物活性无明显差异。VEGF是一类多功能生长因子,能特异性作用于血管内皮细胞,强烈促进其增殖,促进血管形成,并有升高血管通透性的作用。多种细胞有分泌VEGF的功能,并通过旁分泌方式作用于血管内皮细胞。对血管内皮细胞的促有丝分裂作用十分强烈,可明显促进血管生成,能引起血管通透性增加,且是最强烈的引起血管通透性增加的物质。1nmol/L即可起作用,为组胺的50 000倍。用于心血管疾病、肿瘤、创伤修复等。
CAS号:
性质:又称血管通透因子(vascular permeability factor)。1989首先从牛垂体滤泡状细胞培养液中分离纯化。有四种不同形式,成熟单体,分别为121,165,189和206个氨基酸,目前分离得到的VEGF,均由两个相同多肽链通过二硫键构成的同源二聚体,亚基分子量18 000~24 000,总蛋白分子量34 000~46 000。蛋白质表面有许多阳离子,呈强碱性,等电点高,对酸碱热稳定。VEGF是一类糖蛋白,可与肝素结合,多糖链仅与其分泌功能有关,与生物活性无关。VEGF 121/165为可溶性分泌蛋白。VEGF 189/206几乎都结合在质膜或基底膜上的含有肝素的蛋白聚糖上。四种VEGF的生物活性无明显差异。VEGF是一类多功能生长因子,能特异性作用于血管内皮细胞,强烈促进其增殖,促进血管形成,并有升高血管通透性的作用。多种细胞有分泌VEGF的功能,并通过旁分泌方式作用于血管内皮细胞。对血管内皮细胞的促有丝分裂作用十分强烈,可明显促进血管生成,能引起血管通透性增加,且是最强烈的引起血管通透性增加的物质。1nmol/L即可起作用,为组胺的50 000倍。用于心血管疾病、肿瘤、创伤修复等。
说明:补充资料仅用于学习参考,请勿用于其它任何用途。
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