As a new generation of progesterone product,norgestimate is widely used as an oral contraceptive,acne therapy,and hormone replacement therapy for menopausal symptoms in women.

OBJECTIVE To establish a HPLC-UV assay for the determination of norelgestromin(NGMN, the major active metabolite of norgestimate) in serum samples and to study its pharmacokinetics in rats.

As a new generation progesterone product, norgestimate is superior to the second-generation progesterone product levonorgestrel and the third-generation progesterone products-desogestrel and gestodene in terms of pharmacological, pharmacodynamic, toxicological and clinical aspects, as well as its safety and stability profiles.

HNMR and CNMRspectrums of dienogest were investigated and completely assigned by combina- 13 tion of 2D-NMR techniques such as H-1H COSY, HMQC and HMBC.

Application of Second Derivative Spectrometry to the Determination of Quinestrol and of Spectrophotometry to the Norgestrel of Drphylline in Compound Preparation;

OBJECTIVE:Tostudythepermeabilityofleucine-methylglutamate-glutamicacidcopolymerfilmstonorgestrelandtheefectontheirpermeability.

New light on nomegestrol acetate pharmacological profile;