1) Proinsulin
[英][,prəu'insjulin] [美][pro'ɪnsəlɪn]
胰岛素原
1.
The Significance of Serum Proinsulin and Proinsulin to Insulin Ratio in Hyperthyroid Patients for the Diagnosis of Early Islet β-cell Dysfunction;
胰岛素原、胰岛素原/胰岛素比值在诊断甲亢患者早期胰岛β细胞功能受损中的价值
2.
Change of concentrations of true insulin,proinsulin in patients with coronary heart disease,and the probable relationship to serum lipid;
冠心病患者血清真胰岛素、胰岛素原水平的变化及其与血脂的关系
3.
Effect of cholera toxoid-proinsulin conjugate and cholera toxin B sub unit admixtures on spontaneous autoimmune diabetes;
霍乱毒素B亚单位-胰岛素原融合蛋白抗糖尿病
2) Human proinsulin
人胰岛素原
1.
Study on the Recombining Conditions Between A and B Chains of “Mini-C” Human Proinsulin Analog and Human Proinsulin;
小C肽人胰岛素原类似物(B-Arg-Arg-A)和人胰岛素原(B-C-A)A、B链重组条件的研究
2.
By using the site-directed mutagenesis technique,encoding-box of A11 amino acid residue and A12 amino acid residue of human proinsulin gene are exchanged and the [CysA11Ser,SerA12Cys]-human proinsulin mutant gene is constructed.
采用定点突变技术,将人胰岛素原基因编码框中A11位氨基酸残基与A12位氨基酸残基进行了互换,构建了[CysA11Ser,SerA12Cys]人胰岛素原突变基因。
3.
A goatβ-lactoglobulin(BLG) regulatory sequences, enhancer sequence, mark gene (Neo gene) and human proinsulin genomic DNA were used to construct human proinsulin mammary gland-specific expression vector.
本实验室已经用人胰岛素原基因组DNA与山羊乳蛋白调控序列、CMV增强子序列以及新霉素抗性基因构建了人胰岛素原基因乳腺特异性表达载体BIC13。
3) preproinsulin
[,pri:prəu'insjulin]
前胰岛素原
1.
Methods Insulin levels and preproinsulin mRNA expression were analysed by RT PCR and incubated in vitro.
方法 利用胰岛体外培养方法及RT PCR技术 ,检测胰岛素分泌和前胰岛素原mRNA的表达。
2.
Ghrelin promotes preproinsulin mRNA expression and glucose-induced insulin secretion by islets isolated from rats;
(2 )在培养液中加入不同浓度Ghrelin 10 - 1 2 ～ 10 - 8mol L预处理 2 4h后 ,用RT PCR方法检测胰岛内前胰岛素原mRNA表达 ,并测定不同浓度葡萄糖 (5 6mmol L ,16 7mmol L)刺激时胰岛素分泌量。
4) proinsulin C-peptide
胰岛素原C肽
1.
Objective: To investigate the effects of equal mole of insulin and proinsulin C-peptide on the functions of cultured rat retinal Muller cells and bovine retinal microvascular endothelial cells.
目的：观察胰岛素原C肽对体外培养的视网膜Müller细胞和微血管内皮细胞的影响，及其与胰岛素的相互作用。
5) human proinsulin gene
人胰岛素原基因
1.
Construction and identification of the human proinsulin gene recombinant expressing mature insulin in exopancreas;
人胰岛素原基因胰外表达重组体的构建及鉴定
2.
Package of recombinant retroviral vector carrying modified human proinsulin gene and identification of virus titer;
人胰岛素原基因的包装及增殖
3.
Objective To study primarily the safety of transfering recombinant human proinsulin gene plasmid(RHPGP)into diabetic rats induced by streptozotocin.
目的初步研究重组人胰岛素原基因逆转录病毒载体质粒(RHPGP)在糖尿病大鼠体内的安全性。
6) proinsulin gene
胰岛素原基因
1.
Effect of rat proinsulin gene therapy by intramuscular injection on blood glucose in streptozotocin-induced diabetic rats;
肌肉注射大鼠胰岛素原基因治疗糖尿病大鼠的研究
2.
Aim To study the effect of proinsulin gene therapy on diabetic rats, and construct pseudo- β cell line.
方法 (1)从大鼠胰腺组织中提取总RNA,通过逆转录-聚合酶链反应(RT-PCR)法获得大鼠胰岛素原基因cDNA全长序列,并经EcoR Ⅰ和Hind Ⅲ酶切后,应用基因重组和分子克隆的方法与真核细胞表达质粒pCMV-Script Vector构建重组表达质粒pCMV/proinsulin。
补充资料：胰岛素原
分子式：
CAS号：
性质：是一条含有86个氨基酸的多肽生物活性低。在折叠后从中间切去23肽(C肽)后，形成由A链及B链组成的双链多肽，即为有活性的胰岛素。加工工作由体内蛋白酶(如胰蛋白酶)完成。
CAS号：
性质：是一条含有86个氨基酸的多肽生物活性低。在折叠后从中间切去23肽(C肽)后，形成由A链及B链组成的双链多肽，即为有活性的胰岛素。加工工作由体内蛋白酶(如胰蛋白酶)完成。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条