Genetic variants of pregnane X receptor in Chinese healthy Han;

Recently identified nuclear receptors,such as the pregnane X receptor,the constitutive androstane receptor,and the vitamin D-binding receptor,play an important role in the induction of metabolizing enzymes an.

The pregnane X receptor(PXR;NR1I2) is an important component of the body′s adaptive defense against xenobiotics including drugs.

Method: Transient cotransfection reporter gene assays were performed with pCI-hPXR-neo,pGL3-CYP3A4-Luc and β-galactosidase expression plasmid in HepG2 cells.

SD (sprague-dawley) rat(Rattus norvegicus) hepatocytes were treated with clofibrate and the express levels of its PXR (pregnane X receptor) and CYP3A1 (cytochrome P450 3A1) were determined by Western blot and RT-PCR.

Single nucleotide polymorphisms of pregnane X receptor gene NR1I2 in Chinese healthy Han;

Genistein,coumestrol and quercetin activate pregnane X receptor-mediated transcription of CYP3A4;

Effects of Jingqianping granule on expression levels of estradiol receptor alpha and progesterone receptor in hypothalamus of premenstrual syndrome model rats with liver-qi invasion;

Research of 5-Aza-2′-deoxycytidine inducing progesterone receptor demethylation;

Demethylation of progesterone receptor in leukemia cell line induced by DNMT1 antisense oligonucleotide wrapped in liposome;

Methods The expression of P33ING1b,P53,oestrogen receptor(ER),and progesterone receptor(PR) of 86 primary invasive breast cancers and 19 juxtacancerous tissue were detected with immunohistochemical methods.

OBJECTIVE:To discuss the effects of Rujieping capsule on estrogen receptor(ER) and progesteron receptor(PR) of pathological tissues in rats with hyperplasia of mammary glands.