Eight salicylaldehyde-5-ene-norcanthari dinhydrazone and analogus(1～8)were prepared from N-amino-5-ene-norcantharidin amine by condensation with sali-cylaldehyde,cinnamylaldehyde,benzaldehyde,o-nitro-benzaldehyde,N,N-dimethylaminobenzaldehyde,ace-tophenone,2-(6-methoxy)-acetonaphthone and ethylacetoacetate respectively in absolute ethanol for two tothree hours.

Quantification of norcantharidin emulsion using anion-exchange HPLC;

Characterization and in vitro release of chitosan nanoparticles loading norcantharidin;

Intenstinal absorption mechanism and in vitro-in vivo correlation of norcantharidin nanoparticles

In vitro and in vivo assesemet of sodium norcantharidin lipid microsphere;