It was found that there is the greatest influence on the biosynthesis of biotechspiramycin by adding 0.

Effects of isovaleric acid on the biosynthesis of biotechspiramycin were carried out in order to improve the percentage of isovalerylspiramycin Ⅲ and total isovalerylspiramycin of multi-components biotechspiramycin.

Biotechspiramycin was produced by a gene-engineered Streptomyces spiramyceticus strain named WSJ-1-195,which is constructed through integrating the 4"-isovaleryltranferase gene cloned from the carbomycin producing strain into the chromosome of S.

Study on Metabolism and Pharmacokinetics of Bitespiramycin in Vivo;

The stability of bitespiramycin in both phosphate buffer solution and fermentation broth at different temperature as well as in the mixing phase of aqueous phase and butyl acetate in the presence of alkali was investigated.

In previous research it was proved that low ammonium ion concentration in the complex media had negative effect on the titer of bitespiramycin fermentation though percentage of isovalerylspiramycin was greatly enhanced.

Objective To investigate the effect of shear force on the fermentation of biotechmycin.

Biotechmycin is a new antibiotic produced by a stable genetically-engineered strain WSJ-1 which is constructed through gene transformation and homologous recombination.

In the present study,13 antifoams covering 4 types were investigated base on theirs physical and physiological effects on the biotechmycin producti.

Studies on Space-Flight Breeding of Genetically Engineered Strain of Biotechmycin;

Effect of Temperature and pH Value on the Stability of Bitespiramycin in the Process of Separation and Purification;

Simultaneous Determination of Residual Spiramycin and Tylosin in Aquatic Products by HPLC;

Spiramycin extraction by membrane separation;