1) amination
胺基化
1.
2-(N,N-biscarboxymethyl)aminomethyl-6-benzoyl-4-methylphenol was synthesized from 4-methylphenol through a sequence of reaction, esterfication by benzoyl chloride, Fries rearrangement catalyzed by AlCl_3 without any solvent, chloromethylation by formaldehyde and concentrated HCl, amination by diethyl iminodiacetate using TEA as a proton absorbent, hydrolysis by Ba(OH)_2 solution.
以对甲酚为原料,在无溶剂、无AlCl3催化条件下利用Fries重排、氯甲基化、胺基化、水解等反应合成2 (N,N 二羧甲基)氨甲基 6 苯甲酰基 4 甲基苯酚。
2.
2,6,6-Trimethyl-2-cyclohexen-1-aldehyde was prepared from citral undergo amination, cyclization and hydrolysis reaction, mechanics of the reactions is analysed, product content greater than 97%, yield is 86.
以柠檬醛为原料,经胺基化,环化,水解三步反应得到2,6,6-三甲基-2-环己烯-1-甲醛,含量97%以上,产率86。
2) N-alklation
胺烷基化
1.
Methods: Starting from styrene oxide,N-methylethanolamine and 2aminonicotinic acid,the target compound was synthesized via 6 reactive steps involving nucleophilic ring-opening,chlorination,alkalinization,reduction,N-alklation and cyclization.
方法:以N-甲基乙醇胺、氧化苯乙烯和2-氨基烟酸为原料,经亲核开环、氯代、碱化、还原、胺烷基化和环合6步制得了抗抑郁药米氮平。
3) aminomethylation
[,æminəu,meθi'leiʃən]
胺甲基化
1.
Study on the modification of aminomethylation of partially hydrolyzed PAM and Its application in sugar manufacture;
部分水解的聚丙烯酰胺的胺甲基化改性及其在制糖应用研究
2.
After aminomethylation reaction,non-alpha-tocopherols aminomethylated products were extracted by solvent.
对原料进行胺甲基化反应后,用溶剂萃取非α-生育酚胺甲基化产物。
4) Amidocarbonylation
胺基羰基化
1.
Study on the Catalysis of Cobalt-Phosphines for Paraformaldehyde Amidocarbonylation;
钴－膦配合物催化多聚甲醛胺基羰基化反应的研究
5) amino functionalization
胺基官能化
6) isobutylamination
异丁基胺化
1.
Amprenavir in overall yield of 73% was obtained from(2S,3S)-3-(t-butoxy)-amido-1,2-epoxy-4-phenylbutane via isobutylamination,N-4-nitrobenzene sulfonylation,reduction,deprotection,and then condensation with 7.
以(2S,3S)-1,2-环氧基-3-叔丁氧酰胺基-4-苯丁烷为原料,经过异丁基胺化、N-对硝基苯磺酰化、还原、脱保护后再与(S)-3-羟基四氢呋喃-琥珀酰亚胺基碳酸酯(7)缩合制得安普那韦,总收率73%,其结构经1H NMR和MS确证。
补充资料：酰基酰胺基化反应
分子式：
CAS号：
性质：烯烃用四氟化酰基硼和腈处理，在烯键上引入酰基和酰胺基，生成。此加成反应遵守马尔科夫尼科夫规则，亲电的酰基进入到氢原子较多的烯键碳原子上。
CAS号：
性质：烯烃用四氟化酰基硼和腈处理，在烯键上引入酰基和酰胺基，生成。此加成反应遵守马尔科夫尼科夫规则，亲电的酰基进入到氢原子较多的烯键碳原子上。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条