Study on the synthetic technique of the inactivator of dihydropyrimidine dehydrogenase 5-ethynyluracil;

OBJECTIVE:To analyze the current situation and trends of the marketing of 5α-reductase inhibitor.

Objective To investigate the expressions of insulin-like growth factor-Ⅰ(IGF-Ⅰ), insulin-like growth factor-Ⅱ(IGF-Ⅱ) and insulin-like growth factor-ⅠR (IGF-ⅠR) in human prostatic hyperplasitic tissues influenced by 5α-reductase inhibitor on the level of protein.

Objective To observe the effect of simvastatin,a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor,on the expression of endothelin-1(ET-1)in cultured vascular endothelial cell.

Objective: To identify the role of 5α-reductase in the spermatogenesis of male rats by studying the effect of two 5α-reductase inhibitors,Epristeride and Finasteride,on the spermatogenesis in male Sprague-Dawley(SD) rats.

(2)To investigate the expressions of IGF-1(insulin -like factor-1), PCNA(prolifeation cell nuclear antigen) and Caspase3 in human prostatic hyperplastic tissues influnenced by 5α-reductase inhibitor on the level of protein.

Synthesis of a potent human 5a-reductase inhibitor epristeride;

Synthesis of aldose reductase inhibitor fidarestat;

Progress in research of aldose reductase inhibitors in traditional medicinal herbs;

A high throughput screening method established by us was applied for screening aldose reductase inhibitors from thousands of strains of actinomycetes and fungi,as a result,a strain,F01-195 with the positive activity was picked out.