Based on RAFT polymerization, in this thesis, some polymeric nano/microspheres were synthesized and stereoregular PMMA were prepared, which are summarized as the following:(1) The temperature-responsive chitosan-based nanoparticles were synthesized by free radical polymerization of N-isopropylacrylamide (NIPAM) at 60oC in the presence of RAFT-chitosan agent.

The details are described as below:Firstly,the inorganic magnetic particles are the key factors in influencing the properties of magnetic polymer nanospheres.

Studies on cetyl-chitosan nanosphere as carriers for paclitaxel;

Preparation and Characterization of PS/TiO2 Composite Nanospheres;

Study on Encapsulation of Plasmid DNA in Poly(Ethylene Glycol)-Poly(Benzyl L-Glutamate) Copolymer Nanospheres and its Characteristics in Vitro;

The Preparation of Berbamine-paclitaxel Nanoparticles and Evaluation of Its Synergistic Antitumor Effect in Vitro

Preparation and evaluation of alginate nanoparticle simultaneous delivery of doxorubicin and Tf antibody

The new approach for the preparation of the MAF/PCL micelles by self-assembly of a core-shell structure in aqueous solution with PFA chain fragment and PCL as the core and PAA chain fragment in MAF to form complex nanosize micelles and can be further crosslinked to get core-shell structure nanoparticles.