1) Hantzsch cyclization
Hantzsch环化
1.
Hantzsch cyclization with cinnamyl 3-aminocrotonate produced new calcicum antagonist pranidipine under mild conditions.
专利[4] 报道了 3 氨基 2 丁烯酸甲酯 (2 )和 2 (3 硝基亚苄基 )乙酰乙酸肉桂醇酯 (3 )发生Hantzsch环化反应合成普拉地平 (1 )。
2.
2-Methoxyethyl 2-(3-nitrobenzylidene) acetoacetate derived from the former reacted with cinnamyl 2-aminocrotonate derived from the latter under mild Hantzsch cyclization conditions produced new calcium antagonist cilnidipine.
以双烯酮为原料 ,分别与乙二醇单甲醚和肉桂醇进行酯化反应制得乙酰乙酸 - 2 -甲氧基乙酯和乙酰乙酸肉桂酯 ,前者与间硝基苯甲醛缩合生成的 2 - (3-硝基亚苄基 )乙酰乙酸 2 -甲氧基乙酯和后者的氨化产物 3-氨基 - 2 -丁烯酸肉桂酯再进行 Hantzsch环化反应制得新型钙拮抗剂西尼地平。
3.
1,4 Dihydro 2,6 dimethyl 4 (3 nitrophenyl) 3,5 pyridinedicarboxylic acid bis(2 methoxyethyl)ester was synthesized by esterfication, condensation, ammonization and Hantzsch cyclization from diketene, in total yield of 71%.
以双乙烯酮和乙二醇单甲醚为原料 ,经酯化、缩合、氨化和 Hantzsch环化等反应合成了 1 ,4-二氢 -2 ,6-二甲基 -4-(3 -硝基苯基 ) -3 ,5 -吡啶二羧酸二 (2 -甲氧基乙基 )酯 ,总收率 71 %。
2) Hantzsch esters
Hantzsch酯
1.
The asymmetric transfer hydrogenation of C=C,C=N and C=O utilizing the Hantzsch esters as the hydrogen source in the presence of Brnsted acid type organocatalyst,could be carried out with high yields and excellent enantioselectivities under mild conditions.
以Hantzsch酯为氢源,采用Brφnsted酸作有机催化剂催化C=C、C=N、C=O的不对称氢转移反应,在温和条件下即可得到较高的产率和良好的对映选择性,简要评述了这一领域的最新研究进展。
3) Hantzsch reaction
Hantzsch反应
1.
1,4-Dihydropyridine derivatives(1a~1d) were synthesized by improved Hantzsch reaction of aromatic aldehyde, ethyl acetoacetate and NH4HCO3 in a closed system filled with nitrogen gas under refluxing.
采用改进的Hantzsch反应,在氮气保护下的封闭体系中回流芳香醛、乙酰乙酸乙酯和NH4HCO3,合成了1,4-二氢吡啶衍生物(1a~1d),其结构经1HNMR,IR和元素分析确认。
2.
dimethyl-4-(2-nitrophenyl)-3,5-dicarboxymethoxy-1,4-dihydrpyridine(Nifedipine)is synthesized by Hantzsch reaction in which 2-nitro-benzaldehyde, methyl acetoacetate, ammonia or ammonium bicarbonate are used as raw materials.
以乙酰乙酸甲酯、邻硝基苯甲醛、18%氨水或碳酸氢铵为原料,经Hantzsch反应合成2,6-二甲基-4-(2-硝基苯基)-3,5-二甲氧酰基-1,4-二氢吡啶(硝苯吡啶)。
3.
There occurs Hantzsch reaction of the formed formaldehyde with ammonia and 2,4-pentanedione and forms 3,5-diacetyl-1,4-dihydropyridine at pH of ≈6.
建立了一种新的测定羟自由基的电化学方法 ,Fenton反应产生的羟自由基氧化二甲亚砜 (DMSO)生成的甲醛与乙酰丙酮、氨发生Hantzsch反应 ,产物3,5_二乙酰基_1,4_二氢吡啶在 -1。
4) Hantzsch 1,4-dihydropyridine
Hantzsch 1,4-二氢吡啶
5) Hantzsch dihydropyridine derivatives
1,4-二氢Hantzsch吡啶衍生物
6) cyclization
[英][,saikli'zeiʃən] [美][,saɪklɪ'zeʃən, ,sɪklɪ-]
环化
1.
Effect of the molecular cyclization on the structure and properties of polyacrylonitrile fibers;
PAN分子环化行为对纤维结构及性能的影响
2.
Application of Simulated Annealing:Study on Relationship between Conformation of Linear Peptides and Their Cyclization Yields;
模拟退火方法研究线性肽构象与环化的关系
3.
Synthesis of p-cymene by D-72 sulfoacid resin catalysis citral cyclization
D-72磺酸树脂催化柠檬醛环化合成对伞花烃
补充资料：Hantzsch pyrrole synthesis
分子式：
CAS号：
性质：α-氯代醛或酮在氨(或胺)存在下与β-酮酸酯反应，缩合成吡咯衍生物，是合成这类化合物的重要方法。
CAS号：
性质：α-氯代醛或酮在氨(或胺)存在下与β-酮酸酯反应，缩合成吡咯衍生物，是合成这类化合物的重要方法。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条