The distereoisomeric mixture of cyanodimethylmethoxycarbonylmethylbutyrolactam,which is the important intermediate of tolyporphin A,was synthesized with total yield of about 10% from 2,3-butandione and malononitrile through condensation,hydrolysis,amination,cyano-substitution and esterification with diazomethane.

2-Bromo-5-formyl -3-methylpyrrole is an important intermediate of tolyporohin.

In this dissertation, the methodsto synthesize tolyporphin model and its segments were summarized through the analysisand comparison to various synthesis methods of chlorins and pyrrole derivativ.

In this dissertation,the methods to synthesize tolyporphin model and its segments were summarized through the analysis and comparison to various synthesis methods of chlorins and pyrrole derivatives.

Effects of Substitution on the Structure and Property of Porphin;

DFT study in inner hydrogen atoms transfer mechanism of porphine;

The graph-theoretical method is used to deduce the configurations[F 1(x),F 2(x)and F 3(x)],“configuration -mirror image”[R 1(x),R 2(x)and R 3(x)],chiral configurations[ N 1(x),N 2(x)and N 3(x)],achiral configurations[M 1(x),M 2(x)and M 3(x)]of alkyl substituted [14]annulene,[18]annulene and porphine.

The geometries of the protonation process of porphine were calculated by using AM1 MO method.