Research on the headspace gas chromatography for the determination of residual solvent in Sivelestat Sodium Hydrate;

Determination of compound Sivelestat Sodium Hydrate and its related substances by HPLC Gradient Elution Method;

The pre-clinical pharmacology and mechanism of sivelestat sodium,a novel neutrophile elastase inhibitor;

Sivelestat sodium reduces cerebral ischemia-reperfusion injury in rats

Results:Sivelestat sodium(10-8、10-7 and 10-6mol/L)increased the activity of neurons,reduced the leakage rate of LDH,increased the activity of SOD and reduced the content of MDA.

Protective effects of sivelestat against acute lung injury during cardiopulmonary bypass in dogs;

Application of Sivelestat in the Treatment of Acute Lung Injury;

Protective Effccts of Sivelestat Sodium on Ischemia-Reperfusion Injury after Rat Left Unilateral Lung Orthotopic Ttransplantation

But in China, until a kind of epidemic disease called ‘SARS’ which was found in Guangdong province of China, and it’s infectivity is so smart that can transmit pathogen through a short distance, lucubrating of the sivelestat sodium hydrate became.

Objective:Tostudy the effect of Sivelestat sodium hydrate(ONO-5046)on brain proteomics in rats with cerebral ischemia/ reperfusion(CI/R).

Identification of degradation products in raw materials of sivelestat by LC-MS/MS;