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1)  hydroxycamptothecin
羟喜树碱
1.
Effect of liposomes on the lactone moiety of hydroxycamptothecin;
脂质体对羟喜树碱内酯环的保护
2.
Tumor targeting effect and anti-tumor activity of hydroxycamptothecin loaded stealth niosomes with different polyethylene glycol chain length;
聚乙二醇修饰对羟喜树碱隐形纳米囊泡的肿瘤靶向和抑瘤作用的影响
3.
Determination of Hydroxycamptothecin Liposome for Injection by HPLC;
RP-HPLC法测定注射用羟喜树碱脂质体含量
2)  HCPT
羟喜树碱
1.
A HPLC-ELSD method for assay of impurity in HCPT liposome for injection
HPLC-ELSD测定注射用羟喜树碱脂质体中溶血磷脂酰胆碱的含量
2.
Objective To study the concentration and pharmacokinetic parameter after the injection of hydroxycamptotheinum (HCPT) nanoparticles in rabbits.
目的考察纳米羟喜树碱注射用灭菌粉末经静脉注射给药后在家兔体内的药动学特征。
3.
HCPT is the only one specific inhibitor in topoismerase in clinic.
羟喜树碱(Hydroxylcamptothecine,HCPT)是目前唯一用于临床的拓扑异构酶Ⅰ特异性抑制剂,可用于原发性肝癌、胃癌、头颈部癌、膀胱癌及直肠癌、白血病等多种恶性肿瘤的治疗,与其他肿瘤药物相比疗效高、毒性低、无交叉耐药性,是目前治疗多种恶性肿瘤疗效较好的化疗药物,但仍具有骨髓抑制作用和消化道毒性。
3)  hydroxycamptothecine
羟喜树碱
1.
Pharmacokinetics of hydroxycamptothecine injection in cancer patients;
羟喜树碱注射液在肿瘤患者体内的药动学
2.
Observation on clinical safety of topotecan and hydroxycamptothecine in treating patients with brain metastatic carcinoma;
拓扑替康、羟喜树碱治疗脑转移癌的临床安全性观察
4)  Hydroxycamptothecin
羟基喜树碱
1.
Evaluation of 2-Hydroxypropyl-β-Cyclodextrin as Solubilizing/Stabilizing Agent for Hydroxycamptothecin;
2-羟丙基-β-环糊精对羟基喜树碱的增溶及稳定作用研究
2.
Preparation and in vitro drug-release behavior of hydroxycamptothecin semisolid lipid nanoparticles;
羟基喜树碱半固体脂质纳米粒的制备和体外释药特性
3.
Preparation of hydroxycamptothecin liposomes and its encapsulation rate determination;
羟基喜树碱脂质体的制备及其包封率测定
5)  hydroxycamptothecinum
羟基喜树碱
1.
Quantitative analysis of hydroxycamptothecinum and its injection by HPLC;
HPLC测定羟基喜树碱及其注射液的含量
2.
Determination of Hydroxycamptothecinum by Capillary Zone Electrophoresis;
高效毛细管区带电泳法测定羟基喜树碱注射液的含量
3.
Voltammetric Behavior of Hydroxycamptothecinum at Single-Wall Carbon Nanotube Modified Electrode and Its Analytical Application;
羟基喜树碱在单壁碳纳米管修饰电极上的伏安行为及应用
6)  hydroxycamptothecine
羟基喜树碱
1.
Change of survivin gene expression in gastric cancer cell line BGC-823 induced by hydroxycamptothecine;
Survivin在羟基喜树碱诱导胃癌细胞株BGC-823凋亡过程中的变化及其意义
2.
Study on the effect of hydroxycamptothecine on cell line MUTZ-1 of human myelodysplastic syndromes in vitro;
羟基喜树碱对人骨髓增生异常综合征MUTZ-1细胞体外作用的研究
3.
Assay of Concentration of Hydroxycamptothecine in Plasma and Tissues of mouse by Fluorospectrophotometry;
测定小鼠血浆及组织中羟基喜树碱浓度的研究
补充资料:羟喜树碱
分子式:
CAS号:

性质:黄色柱状结晶,不溶于水,微溶于有机溶剂。溶液具有荧光。以3-腈基-4-甲基-2-吡啶酮-5-羟酸乙酯为原料,经环合、氧化、醚化、缩合、氢化还原、酯化、硝化、转化、环合、缩合、氧化、脱醚化等反应而制得。本品为喜树碱相似,但抗瘤谱广,毒性较小,疗效高。临床主要用于原发性肝癌,也用于胃癌、食管癌、头颈癌、膀胱癌及急性粒细胞性白血病。

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