Progress on Production of D-calcium Pantothenate and D-panthenol by Biotechnology;

A synthesis method for D-panthenol is described that involves synthesis of the key intermediate D-pantolactone , by optical resolution of DL-pantolactone by using a fungal enzyme cells.

Properties of d-pantothenyl alcohol and its applic ations in hair protecting products a nd cosmetics for partial use are intr o-duced.

D-Pantothenyl alcohol, also called ortho-vitamin 85, is an important nutrition suppled substance.

A reversed-phase high performance liquid chromatographic method has been devel oped for the simultaneous determination of allantoin and panthenol in cosmetics on a YWG C18 column (250 mm×46 mm id, 10 μm), using methanol-002 mol/L phosphate (10∶90, v/v) as mobile phase.

A method to analyse the content of D-calcium pantothenate by high performance liquid chromatography was introduced.

This paper introduces the D-calcium pantothenate production methods and uses,and its market prospects are analyzed.

At present,there are over 10 producers of D-calcium pantothenate in China with total capacity over 9600 t/a,the main producers of Dcalcium pantothenate are Zhejiang Hangzhou Xinfu Pharmaceutical Co.