Catalyted by Cu, Phenol condensed with o-chloro nitrobenzene in DMSO with the presence of potassium hydroxide to get o-nitrodiphenyl ether, followed by catalytic hydrogenation with 5% Pd/C to yield target compound.

The optimal reaction conditions were as follows:n(o-anisidine)∶n(sulfuric acid)∶n(sodium nitrite)=1.

Study on catalytic hydrogenation for preparation of o-phenetidine;

Synthesis of an alkylated product of O-Phenetidine;