1) lactosyl isothiocyanate
乳糖基异硫氰酸酯
1.
The reaction of 2,3,6,2',3',4',6'-hepta-O-acetyl-β-lactosyl isothiocyanate (1) with 2-amino-4/6-substituted benzothiazoles 2a-2e gave lactosylthioureas 3a-3e, which were treated with amines in the presence of HgCl2 to afford a series of novel N-alkyl/aryl-N'-(4/6-substituted benzothiazol-2-yl)-N''-perace-tylated lactosylguanidines 4-6.
6'-七-O-乙酰基-β-乳糖基异硫氰酸酯(1)分别与2-氨基-4/6-取代苯并噻唑2a~2e反应,制得糖基硫脲3a~3e,将其在HgCl2作用下与伯胺反应,制得一系列新化合物N-烷基/芳基-N'-(4/6-取代-苯并噻唑-2-基)-N''-(2,3,6,2',3',4',6'-七-O-乙酰基-β-乳糖基)胍4~6。
2) glycosyl isothiocyanate
糖基异硫氰酸酯
1.
Fifteen target compounds were synthesized with the following three steps: amino acids were protected to form carbobenzoxyamino acid methyl esters, the carbobenzoxyamino acid methyl esters reacted with hydrazine to give carbobenzoxy amino acid hydrazides, and treatment of the carbobenzoxy amino acid hydrazides with glycosyl isothiocyanates afforded 3a~3o in 65%~86% yields.
通过对5种氨基酸酯化和氨基保护得到苄氧羰基氨基酸甲酯,经肼解制备苄氧羰基氨基酸酰肼,然后分别与3种不同的糖基异硫氰酸酯反应,制备了相应的目标化合物15个,且产率均在60%以上。
2.
The reaction of 2 with glycosyl isothiocyanates 3~5 gave the novel compounds, N-glycosyl-N'-amido thioureas 6~8.
以L-α-氨基酸为起始原料,经酯化、氨基保护、肼解制得N-对甲苯磺酰基-L-α-氨基酸酰肼2,再与糖基异硫氰酸酯3~5反应,得到9种新型N-糖基-N'-酰氨基硫脲6~8,然后在Hg(OAc)2/EtOH条件下关环,合成了一系列新的2-对甲苯磺酰氨基烃基-5-糖氨基-1,3,4-噁二唑类化合物9~11。
3.
The glycosyl isothiocyanates 1a~1c reacted with anhydrous hydrazine gave N-glycosyl- N'-aminothioureas 2a~2c, which then reacted further with 6-substituted-3-formylchromones 3a~3d to give a series of new N-glycosyl-N′-6-substitutedchromon-3-ylmethylideneaminothioureas 4a~4d, 5a~5d, 6a~ 6d.
糖基异硫氰酸酯(1a~1c)与无水肼反应,生成糖基氨基硫脲2a~2c,再与6-取代-3-甲酰基色酮3a~3d反应,得到一系列新的N-糖基-N′-(6-取代色酮-3-基-亚甲氨基)硫脲类化合物4a~4d,5a~5d,6a~6d。
3) rhamnosyl isothiocyanate
鼠李糖基异硫氰酸酯
1.
The nucleophilic addition of rhamnosyl isothiocyanate to substituted 2-aminobenzothiazoles (2a~2f), 2-hydrazinobenzothiazoles (2g~2l), oxidized and nonoxidized 3-hydra- zinocarbon.
以L-鼠李糖为起始原料,制备1-溴-2,3,4-三-O-乙酰基-β-L-吡喃型鼠李糖,然后在甲苯中与Pb(SCN)2作用,得到中间体2,3,4-三-O-乙酰基-α-L-吡喃型鼠李糖基异硫氰酸酯(1)。
4) glucosyl isothiocyanate
葡萄糖基异硫氰酸酯
1.
Refluxing of 2 with glucosyl isothiocyanate(1)in CHCl_3 gave corresponding N,N′-substituted-N″-(2,3,4,6-tetra-O-acetylglucosylthioureylene)phosphoric triamides(3a-3g),and deacetylation in MeOH/NaOMe gave N,N'-substituted-N″-glucosy1 thioureylene phosphoric triamides(4a-4g).
将它们与葡萄糖基异硫氰酸酯在氯仿中回流 ,生成相应的N 芳基 (烷基 ) N′ 芳基 (烷基 ) N″ 2 ,3,4,6 四 O 乙酰基葡萄糖基硫代亚脲基膦酰三胺 ( 3a 3g) ,然后在甲醇甲醇钠中脱去乙酰基得到目标化合物N 芳基 (烷基 ) N′ 芳基 (烷基 ) N″ 葡萄糖基硫代亚脲基膦酰三胺 ( 4a 4g)。
5) xylopyranosyl isothiocyanate
木吡喃糖基异硫氰酸酯
1.
The reaction of 2,3,4-tri-O-acetyl-β-D-xylopyranosyl isothiocyanate 1 and 2-amino-4/6-substituted benzothiazoles 2a~2e gave xylopyranosylthioureas 3a~3e,which then reacted with alkyl/aryl amine in the presence of HgCl_2 to afford a series of new guanidinoxylopyranosides (4a~4e,5a~5e,6a~6e and 7a~7e).
2,3,4-三-O-乙酰基-β-D-木吡喃糖基异硫氰酸酯1与2-氨基-4/6-取代-苯并噻唑2a~2e反应,生成糖基硫脲衍生物3a~3e,再在伯胺存在下经氯化汞脱硫,得到一系列新的胍基木吡喃糖苷类化合物4a~4e,5a~5e,6a~6e,7a~7e,所有新化合物的结构均经IR,~1H NMR,MS谱和元素分析证实,所得产物均为β-构型。
6) glycosyl isothiocyanate
糖基异硫氰酸脂
补充资料:4-氯苯基异氰酸酯
分子式:C7H4NOCl
分子量:153.50
CAS号:104-12-1
性质:该品为无色液体,沸点:203℃,有刺激性气味,有毒。
制备方法:暂无
用途:用作有机合体的中间体。
分子量:153.50
CAS号:104-12-1
性质:该品为无色液体,沸点:203℃,有刺激性气味,有毒。
制备方法:暂无
用途:用作有机合体的中间体。
说明:补充资料仅用于学习参考,请勿用于其它任何用途。
参考词条