The pharmacophore model of p53-MDM2 binding inhibitors was established by the Catalyst software with the training set of 24 inhibitors containing 5 different kinds of structures.

p53 specific inhibitor,pifithrin α,influencing expressions of p53,Bax and MDM2 in colonic epithelial cells injured by hyperthermic chemotherapy;

Interfering with the MDM2-p53 feedback loop leads to p53 (wt) activation,ultimately preventing neoplasia.

Objective To discuss the effect of Qingdushuan on SiHa cells of cervical cancer proliferation and protein expression in PTEN-MDM2-p53 network from the level of cell biology and molecular biology.

Study on the synthesis of new-style phosphorus coke inhibitor intermediate

The effective factors such as: the materials of reactor, reaction temperature,velocity of feeding,the type and the amount of catalyst, the type and the amount of coke inhibitor,which influenced the yield rate of the product were investigated,and the separation methods for purifying 3,5-xylenol was also studied.

The effects of pyrolysis temperature on the rate of coke formation and the coke inhibitor's anti-coking performance were investigate.