Catalyst-free synthesis of 2-amino-7,7-dimethyl-5-oxo-4-aryl-4H-chromene-3-carbonitrile-5,6,7,8-tetrahydrobenzo[b]pyran(2) in water is described.

Recently , Compouds containing Benzo[b]pyran structure is the hotspot of new drugs development, which possess antitumor, choleretic treatment and eliminating urolith, anticoagulation, anti-osteoporosis, anti-inflammatory, anti-fungus, hemangiectasis, reducing blood sugar , antivirus, anti-schistosomiasis, and so on.

One-Pot Synthesis of 2-Amino-3-cyano-4-aryl-7,7-dimethyl-5-oxo- 4H-5,6,7,8-tetrahydrobenzo[b]pyran in Aqueous Medium;

Owing to the special structure and high reactivity of 2-(benzo[d]thiazole-2-yl)- acetonitrile andβ-(2-chloroaroyl)-heterocyclic ketene aminals, we herein developed an excellent strategy for for the synthesis of 4H-benzo[b]pyrans, tetrahydroimidazo -[1,2-a]pyridines and 1,8-naphthyridines derivatives.

Efficient Synthesis of 2-Amino-4-aryl-7,7-dimethyl-5-oxo-4H-5,6,7,8-tetrahydrobenzo[b]pyran-3-carboxylate in Aqueous Media;

Synthesis and Vasorelaxant Activity of Trans-3-hydroxy-4-aminobenzopyran Acetylated Derivatives as K~+ Channel Openers;

Synthesis of cis- and trans-2,4,7-Triaryl-5-oxo-4H-5,6,7,8-tetrahydrobenzopyrans;

Synthesis and Crystal Structure of Ethyl 2-amino-7,7-dimethyl-4-(4′-fluorophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-benzopyran-2-carboxylate in Water;

The convenient synthesis of a natural chromene;

Non-catalytic Synthesis of 2-Amimo-3-cyano- 7,7-dimethyl-4-aryl-5-oxo-5,6,7,8- tetra-4H-chromenes;