Effects of 5-Aza-2’-deoxycytidine on proliferation of human lung cancer cell lines;

Screening of cytidine-producing mutants based on feedback-inhibition resistance of CTP synthetase

Synthesis of 5-Fluorocytidine and 5'-Deoxy-5-fluorocytidine;

Synthesis of 5-Fluorocytidine and 5 -Deoxy-5-fluorocytidine;

Effect of 5-Aza-2'-deoxycytidine on biological behaviors of human breast cancer cell line MCF-7;

OBJECTIVE:To investigate the effects of 5-Az-a-2 -deoxycytidine(5-Aza-CdR) and trichostatin A(TSA) on the proliferation of MDA-MB-435S cells and the expression of tumor suppressor gene maspin.

1 μmol/L, 1 μmol/L, 5 μmol/L,10 μmol/L) of 5-aza-2′-deoxycytidine(5-aza-2dC) were added into culture medium of NPC cell lines for 72 hours′ de-methylation treatment, then methylation status of ANXA1 gene were detected by MSP and mRNA expression were evaluated by RT-PCR.

Study on mechanism of apoptosis induced by Ara-C in leukemia HL-60 cells;

Effects of Ara-C on proliferation/apoptosis and bcl-2 gene expression of HL60 cell;

The mechanisms of inhibitory effect of Ara-C and bufalin on human leukemia cells;