1) Claisen-Schimidt reaction
Claisen-Schimidt反应
1.
Using helicid as starting material,novel E-(4-β-D-allopyranosyloxyphenyl)-1-(4-substituted phenyl)propenone derivatives(1a ～ 1e) have been synthesized by Claisen-Schimidt reaction with 4-substituted hypnone.
以豆腐果苷为原料,与4-取代苯乙酮发生Claisen-Schimidt反应,得到一系列E-4-β-D-吡喃阿洛糖苷-苯乙烯基-4-取代苯酮衍生物1a～1e,再将1a～1e与邻氨基苯硫酚发生1,4-Michael反应,得到2-(4-β-D-吡喃阿洛糖苷-苯基)-4-芳基-2,3-二氢-1,5-苯并硫氮杂衍生物2a～2e,以上化合物均未见文献报道,其结构经1H NMR,IR,MS加以确证,并对2a～2e进行了药理活性筛选。
2) claisen-schmidt reaction
Claisen-Schmidt反应
1.
β-nitrostyrene was synthesized by ultrasonic Henry reaction and the accessory ingredient of alcohol Claisen-Schmidt reaction,using benzaldehyde and nitromethane as raw materials.
分别研究了在超声波辅助Henry反应和甲醇助剂存在Claisen-Schmidt反应的条件下由苯甲醛、硝基甲烷合成β-硝基苯乙烯的反应条件,发现Claisen-Schmidt反应条件下收率最高,产率为84%。
3) aza-Claisen reaction
aza-Claisen反应
4) Schmidt-Claisen reaction
Schmidt-Claisen反应
1.
(E)-3-[4-β-D-Allopyranosyloxyphenyl]acrophenones (3a～3h) with a structure of chalcone were synthesized by Schmidt-Claisen reaction of 4-substituted hypnone with helicid, among which 3c, 3e and 3f are three new compounds.
以豆腐果苷为原料,与4-取代苯乙酮发生Schmidt-Claisen反应,得到一系列查尔酮结构的E-4-β-D-吡喃阿洛糖苷-苯乙烯基-4-取代苯乙酮衍生物3a～3h,其中3c,3e,3f为新化合物。
5) Claisen condensation
Claisen缩合反应
1.
In acid or basic condition the recyclization of the opening product was carried out, and spirocyclic and bridged compounds 11～14 were obtained by intramolecular Claisen condensation.
经retro-aldol重排,环加成产物3开环生成取代环己烯4,在酸和碱性介质中对开环产物进行再环合,经分子内Claisen缩合反应形成螺环和桥环化合物11～14。
6) Claisen rearrangement
Claisen重排反应
1.
Application of bis(indeny)rare - earth hydride in Claisen rearrangement;
二茚基稀土氢化物在Claisen重排反应中的应用
2.
The new synthesis process starts from 2-methyloctanal, then through hydroxyethylenation, transetherification, Claisen rearrangement, hydroxymethylation, hydrogenation to give 3,7- dimethyl-2-tridecanol.
本文利用Claisen重排反应提出了一条全新的合成路线 : 四氢呋喃、吡啶等均经过精制 ,其它原料及试剂均为市售分析纯。
3.
Under microwave irradiation,eight seselin and related derivatives(1a～1h) were synthesized from substituted 7-(1\',1\'-dimethyl-2\'-propargyl) oxycoumarin (4a～4h) by Claisen rearrangement efficiently with a higher yield range of 45%～89% and a regioselectivity of 90%.
该微波反应具有反应完全(转化率>98%)、区域选择性高(角型/线型产物比为9:1)和产率明显高于传统的Claisen重排反应的优点。
补充资料：Claisen rearrangement
分子式：
CAS号：
性质：烯醇或酚的烯丙基醚加热到200℃以上时发生分子内重排，烯丙基从氧原子迁移到碳原子上，称为克莱森重排，反应具有协同的反应机理，即经过芳香性的六电子过渡态。本反应在有机合成中有广泛的应用价值。
CAS号：
性质：烯醇或酚的烯丙基醚加热到200℃以上时发生分子内重排，烯丙基从氧原子迁移到碳原子上，称为克莱森重排，反应具有协同的反应机理，即经过芳香性的六电子过渡态。本反应在有机合成中有广泛的应用价值。
说明：补充资料仅用于学习参考，请勿用于其它任何用途。
参考词条