Six 3,5-diarylpyrazole derivatives were synthesized using aromatic aldehyde and aromatic ketones and hydrazine as starting masteries under ultrasonic and microwave irradiation,and all the products were charactered by H NMR.

CoMFA(comparative molecular field analysis)models of the 1,5-diarylpyrazoles of cyclooxyge-nase-1 selective in hibitors was established using the advanced 3D-QSAR method in order to give a theoret-ical basis to design new inhibitors.

Synthesis and COX-2 inhibitory activities of 1,5-diaryl pyrazole derivatives;