Applications of polyglutamic acid and it s derivatives in the field of new DDS;

In order to reduce the cost of fermentation of polyglutamic acid,Bacillus subtilis CGMCC No.

Polyglutamic acid, a new kind of biodegradable materials, plays a peculiar role in the field of targeting drug delivery, which can be degraded in vivo into its monomer, a essential amino acid, in human.

Main factors effecting the biosynthesis of poly(glutamic acid);

As a kind of biological macromolecules,γ-Poly(glutamic acid) (γ-PGA) is water soluble , biodegradable , edible and non-toxic toward humans and the environment.

Biosynthesis and application of poly(γ-glutamic acid);

Poly(L-glutamic acid)(PLGA)was prepared by removing the benzyl groups from poly(γ-benzyl L-glutamate)(PBLG)through 33%(volume fraction)HBr and acetic acid solution.

Optimization of γ-polyglutamic acid fermentatiom medium by response surface methdology;

Study on fermentation kinetics of γ-polyglutamic acid production by Bacillus subtilis;

Optimization on fermentation conditions ofγ-polyglutamic acid and preliminary analysis on its characters;